This why don’t we conclude that clofazimine was blocking the calcium influx into the immune cells, Liu says. Without enough calcium getting inside a cell, the signaling pathway that turns on the immune response was short-circuited. The Johns Hopkins group also demonstrated that clofazimine tamps down the presence of free of charge calcium in immune cells by disrupting a potassium channel. The combined impact is to turn off a signaling pathway involved in autoimmune disease. Furthermore to Jun O. Liu, authors of this paper are Yunzhao R. Ren, Lover Pan, Curtis R. Chong, Jing Xu, Yongjun Dang, and Jin Zhang, all of Johns Hopkins; Reinhold Penner, Suhel Parvez, and Andrea Fleig, all of the University of Hawaii; and Hongsi Jiang of Northwestern University..‘These outcomes will enable sufferers to have more choices, including less-invasive therapy, for clearing their carotid artery. Physicians will also be able to provide better guidance to their patients concerning benefits and dangers for the many alternative treatments, predicated on an individual’s health history; this should lead to improved individual outcomes. Bailey, M.D., FSCAI, president of Society for Cardiovascular Angiography and Interventions, and chief, division of cardiology, Janey Briscoe Distinguished Seat of Cardiovascular Study and professor of medicine and radiology at the University of Texas Wellness Sciences Middle at San Antonio, Texas.