The study determined Cordes and colleagues found that a beta-1 integrin / FAK / Cortactin signaling pathway critical for HNSCC resistance to radiotherapy. Inhibition beta-1 integrin sensitizes HNSCC cells radiotherapy and delayed tumor growth in xenografted mice. Cordes and colleagues therefore suggest that targeting beta-1 integrin could in combination with radiotherapy and chemotherapy to be used to increase survival in patients with HNSCC.
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