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They take note the potential great things about identifying surrogate markers for COX-2 activity that could be monitored during the period of sunitinib therapy in patients with RCC so that a COX-2 inhibitor such as celecoxib could be administered during COX-2 elevation, therefore sparing the price and toxicity associated with upfront mixture therapy. The experts say: Nevertheless, in the absence of such biomarkers, our data support the study of the initial combination of celecoxib and sunitinib in sufferers with advanced ccRCC. Licensed from medwireNews with authorization from Springer Health care Ltd. All privileges reserved. Neither of these ongoing parties endorse or suggest any commercial products, services, or equipment.. COX-2 inhibitor extends sunitinib activity in renal cell carcinoma By Lucy Piper, Senior medwireNews Reporter The effectiveness of sunitinib for the treating renal cell carcinoma could possibly be enhanced with the addition of a cyclooxygenase-2 inhibitor, study findings display.