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The investigators also discovered that the 12-nanometer-diameter contaminants generated a magnetic signal that was about 75 % stronger than the 6-nanometer-diameter particles. To determine if these manganese-including iron oxide nanoparticles could better identify cancers cells using MRI, the investigators labeled the nanoparticles with the human being cancer-targeting antibody Herceptin. Herceptin, which can be used to treat breast malignancy, binds to a particular protein, referred to as HER2/neu that is overexpressed on certain breast and ovarian tumors. The researchers then added these labeled nanoparticles to a number of human cancer cells growing in culture. Related StoriesScientists explore biodegradable nanomedicine to ruin ovarian cancer cells left behind after surgeryResearchers reveal how charged gold nanoparticles influence structure of DNA and RNANew magnetic field delivery method could help treat traumatic human brain injuryThese experiments showed that the manganese-containing nanoparticles could actually detect tumor cells creating only minimal amounts of the HER2/neu proteins, while regular iron oxide nanoparticles could just detect those cells generating the most HER2/neu.