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Over the remaining 2461 patient-years of follow-up 28 hemorrhages occurred, corresponding to an annual hemorrhage price of 1 1.1 percent. The researchers note that most of the hemorrhages occurred after the age of 40 years. Indeed, females with an AVM got a 7.91-fold improved risk for hemorrhage weighed against women without the problem, which risen to 18.12-fold when the analysis was limited to patient follow to the age group of 40 years up. When the united group reanalyzed the data, excluding hemorrhages on presentation and using patient-years of follow up than total since birth rather, the entire annual hemorrhage rate increased to 4.8 percent. Provided the study findings, the researchers recommended the protocol presently used in their medical center where AVMs uncovered during being pregnant are treated early.