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‘We are able to collect and evaluate that scattered light searching for the tell-tale symptoms of dysplasia. Significantly, the technique is noninvasive so no tissue is taken and no dyes or contrast agents are needed.’ Specifically, they want to spot characteristic adjustments within the cells of the epithelium. In the case of pre-cancerous cells, the nuclei are misshapen and bigger than normal cells, plus they scatter light in their own unique way. ‘The important thing for clinicians has been in a position to detect these adjustments in the nuclei in cells just below the surface, which can not be detected by just looking at the liner of the colon through an endoscope alone,’ Wax said. The technology that Wax and his group developed for cancer detection is called angle-resolved low coherence interferometry .