.. BioCryst Pharmaceuticals announces BCX4208 compound outcomes for treating gout BioCryst Pharmaceuticals, Inc. announced positive top-line outcomes from its randomized, double-blind, multi-center, placebo-controlled Stage 2 study made to evaluate the urate-reducing activity and protection of several dosages of BCX4208 only and in conjunction with selected dosages of allopurinol administered once-daily. The principal endpoint was alter in serum the crystals concentration after 21 days of treatment in comparison to baseline concentration ahead of treatment. Eighty-seven gout sufferers with sUA concentrations higher than or add up to 8 mg/dL had been randomized to get BCX4208 at daily dosages of 20 mg, 40 mg and 80 mg administered orally as monotherapy or in conjunction with allopurinol at daily dosages of 100 mg, 200 mg and 300 mg orally administered.Giannobile provide the first reported individual case of treatment of a large periodontal osseous defect with a 3D imprinted, bioresorbable, patient-specific, polymer scaffold and signaling growth factor. A patient diagnosed with serious destruction of periodontal cells provided for treatment to protect his dentition. The treated site remained intact for 12 weeks following therapy but failed at 13 months. Although this case was unsuccessful lengthy term, the authors believe the strategy warrants further research on how 3D printing could be applied for the reconstruction of oral and craniofacial anomalies. In a review titled ‘3D Bioprinting for Regenerative Dentistry and Craniofacial Cells Engineering’ reviewers Fabian Obregon, Cedryck Vaquette, Saso Ivanovski, Dietmar Luiz and Hutmacher Bertassoni describe different 3D bioprinting methods.