It is important that a mutant protein incapable CXCL10 mediating cellular attraction still protected mice in the model of pulmonary fibrosis in a syndecan-4 – dependent manner. Since the mutant CXCL10 protein should have incapable mediating cellular attracting few side effects, in contrast to the normal protein, the authors suggest that it may be a new drug for the treatment of pulmonary fibrosis provide. The authors Title: Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4.. The tests revealed that the expression of the protein syndecan-4 increases in their mouse model of pulmonary fibrosis, and that increased in mice lacking syndecan-4. Further analyzes showed that syndecan – a natural protection against a natural protection against pulmonary fibrosis provided by interaction with the protein CXCL10, cellular attractant known antifibrotic properties.
In the study, analysis of mice given the transport protein NHE4 NHE4 and activity in the rat kidney that NHE4 is important for ammonia transport by MTALH cells and maintain the normal acid-base balance in the body. The authors conclude that NHE4 could fault in individuals with adult renal tubular acidosis, a medical condition that may be removed by the accumulation of acid in the due to a failure due to a failure of the kidneys to acid from the body in urine.. Ammonia is the main component of acid urine.The research 2,000 young women and 1,000 young males will enroll in this multicenter projects by June 2011. – ‘We are grateful for the tremendous support and commitment of Geisinger Health System and in other participating VIRGO stations this important research projects possible,’said Yale School of Public Health Associate Professor in Judith Lichtman, co-principal investigator the study.
Currently, we have National Research Project: detectives of CARE study, results for young women with heart diseases – study Geisinger Health System and Yale School of Medicine scientists, like young people heart attacks to restore through VIRGO a research project which ,, Lung and Blood Institute. Young women with heart attacks about approximately double the risk of in a hospital than males of the same age, said LocalSystem Principal Investigator of Kimberly Skelding a interventional cardiologist, director of Geisinger Women’s Heart and Vascular Health Program and Director of the Heart and circulatory genomics and Cardiovascular Research at the Henry Hood Centre for Health Research. Currently, we have little information available on which accounts for the higher risk of young women with heart disease or how best address it.